isom lab @ UM

We specialize in drug discovery using informatics, robotics, and novel cell-based technologies. We also study the molecular and cellular basis…

new paper in Biology

In this paper, Senior Research Associate Santiago Vilar reports how much the proteome of the SARS-CoV-2 virus has changed over…

new bioRxiv post

In this preprint that is currently under review, graduate student Nick Kapolka reports the surprising discovery that proton-gated coincidence detection…

new paper in JBC

A tour de force by graduate student Jacob Rowe using computational predictions and cell-based experimental validation to bring new insights…

new paper in NRDD

In this piece for Nature Reviews Drug Discovery, Nick Kapolka and I discuss the druggability of the understudied GPCR, hydroxycarboxylic…

new collaborative paper in BJ

In this collaborative project we provided our extensive expertise on the effect of buried ionizable residues on protein structure-function relationships:…

new paper in JBC

Genome stability is essential for engineering cell-based devices and reporter systems. With the advent of CRISPR technology, it is now…