The Isom Lab is supported by a Maximizing Investigators Research Award (MIRA award) from the National Institute of General Medical Sciences to study pH regulation of cell surface receptors. In certain biological scenarios–e.g. endocytosis, cancer, hypoxia, ischemia, nutrient stress, and inflammation–surface receptors encounter acidic conditions that can alter cellular physiology and drug efficacy, Using our combined computational and experimental approaches, we are using our MIRA support to develop a more comprehensive understanding how pH regulates signaling systems, with a particular focus on G protein-coupled receptors, the largest class of cell surface receptors in humans (having more than 800 members).
