In this paper, Senior Research Associate Santiago Vilar reports how much the proteome of the SARS-CoV-2 virus has changed over … More
Author: isom lab
new bioRxiv post
In this preprint that is currently under review, graduate student Nick Kapolka reports the surprising discovery that proton-gated coincidence detection … More
new paper in Structure
In this paper, graduate student Geoff Taghon shows that predictable cholesterol binding sites in GPCRs lack consensus motifs: https://pubmed.ncbi.nlm.nih.gov/33508215/
new paper in JBC
A tour de force by graduate student Jacob Rowe using computational predictions and cell-based experimental validation to bring new insights … More
new collaborative paper in Frontiers in Cell and Developmental Biology
In this paper, we contributed to the Zhang lab’s efforts to understand the regulation of mitochondrial respiratory chain complex levels, … More
new paper in NRDD
In this piece for Nature Reviews Drug Discovery, Nick Kapolka and I discuss the druggability of the understudied GPCR, hydroxycarboxylic … More
new collaborative paper in BJ
In this collaborative project we provided our extensive expertise on the effect of buried ionizable residues on protein structure-function relationships: … More
Sofia Perez wins first prize for her SURF project and seminar on SARS-CoV-2
Congratulations to Sofia Perez, an undergraduate at Notre Dame and our SURF student in this year of COVID-19. She was … More
a bit of local press on our recent innovations and discoveries
new paper in JBC
Genome stability is essential for engineering cell-based devices and reporter systems. With the advent of CRISPR technology, it is now … More